Yuan S, Zheng H, Zheng Z, Yan W. Proteomic Analyses Reveal a Role of Cytoplasmic Droplets as an Energy Source during Epididymal Sperm Maturation.PLoS One , 2013 Oct 14; 8(10):e77466. DOI:10.1371/journal.pone.0077466.

Bao J,
Yuan S, Maestas A, Bhetwal B, Schuster A, Yan W. Stk31 is dispensable for embryonic development and spermatogenesis in mice. Mol Reprod Dev, 2013 Oct; 80(10):786. DOI: 10.1002/mrd.22225.

Xu H
*, Yuan S*, Zheng Z, Yan W. The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis.Asian J Androl, 2013 Nov;15(6):799-805. DOI:10.1038/aja.2013.69.(*Equal contribution)


Lv C, Wang X, Guo Y, Yuan S#Role of Selective Autophagy in Spermatogenesis and Male FertilityCells, 2020, Nov 23; 9(11): 2523. DOI:10.3390/cells9112523.(#Corresponding author)​

Yang W, Wang L, Wang F#Yuan S#Roles of AMP-Activated Protein Kinase (AMPK) in Mammalian Reproduction. Front. Cell Dev. Biol., 2020 Nov 19; 8:593005. DOI:10.3389/fcell.2020.593005. (#Corresponding author)​

​Wang F, Yang W, Ouyang S, Yuan S#The Vehicle Determines the Destination: The Significance of Seminal Plasma Factors for Male Fertility. Int J Mol Sci. 2020 Nov 12;21(22):E8499. DOI: 10.3390/ijms21228499. (#Corresponding author)​

​Zhou S, Feng S, Qin W, Wang X, Tang Y, Yuan S#Epigenetic Regulation of Spermatogonial Stem Cell Homeostasis: From DNA Methylation to Histone Modification. Stem Cell Rev Rep. 2021 Apr; 17(2):562-580. DOI: 10.1007/s12015-020-10044-3. (#Corresponding author)​

Guo S, Chunyu Lv, Ouyang S, Wang X, Liao A, Yuan S#GOLGA4, A Golgi matrix protein, is dispensable for spermatogenesis and male fertility in mice. Biochem Biophys Res Commun. 2020, 529(3):642-646. DOI: 10.1016/j.bbrc.2020.05.170. (#Corresponding author)​

Wang X, Lv C, Guo Y, Yuan S#Mitochondria Associated Germinal Structures in Spermatogenesis: piRNA Pathway Regulation and Beyond.Cells,  2020 Feb 10; 9(2). pii: E399. DOI: 10.3390/cells9020399. (#Corresponding author)​

Wang Z, Xie Y, Wang Y, Morris D, Wang S, Oliver D, Yuan S, Zayac K, Bloomquist S, Zheng H, Yan W. X-linked miR-506 family miRNAs promote FMRP expression in mouse spermatogonia. EMBO Rep. 2020 Jan 7;21(1):e49024. DOI: 10.15252/embr.201949024.


​​​​Zhang J, Dong J, Qin W, Cao C, Wen Y, Tang Y#, Yuan S#Ovol2, a zinc finger transcription factor, is dispensable for spermatogenesis in miceReprod Biol Endocrinol. 2019 Nov 23;17(1):98. DOI: 10.1186/s12958-019-0542-3. (#Corresponding author)​

Dong J, Wang X, Cao C, Wen Y, Sakashita A, Chen S, Zhang J, Zhang Y, Zhou L, Luo M, Liu M, Liao A, Namekawa SH, Yuan S#UHRF1 suppresses retrotransposons and cooperates with PRMT5 and PIWI proteins in male germ cells. Nat Commun. 2019 Oct 17;10(1):4705. DOI: 10.1038/s41467-019-12455-4.(#Corresponding author)

​​Gao H, Wen H, Cao C, Dong D, Yang C, Xie S, Zhang J, Huang X, Huang X, Yuan S#, Dong W#. ​Overexpression of MicroRNA-10a in Germ Cells Causes Male Infertility by Targeting Rad51 in Mouse and Human. Front Physiol. 2019 Jun 18;10:765. DOI: 10.3389/fphys.2019.00765.​ (#Corresponding author)

Zheng C, Ouyang YC, Jiang B, Lin X, Chen J, Dong MZ, Zhuang X, Yuan S, Sun QY, Han CNon-canonical RNA polyadenylation polymerase FAM46C is essential for fastening sperm head and flagellum in mice. Biol Reprod. 2019 Jun 1;100(6):1673-1685. DOI: 10.1093/biolre/ioz083.

​​Wang Z, McSwiggin H, Newkirk SJ, Wang Y, Oliver D, Tang C, Lee S, Wang S, Yuan S, Zheng H, Ye P, An W, Yan W. Insertion of a chimeric retrotransposon sequence in mouse Axin1 locus causes metastable kinky tail phenotype.​ Mob DNA. 2019 May 3;10:17.DOI: 10.1186/s13100-019-0162-7.

 Yuan S*, Liu Y*, Peng H*, Tang C, Hennig GW, Wang Z, Wang L, Yu T, Klukovich R, Zhang Y, Zheng H, Xu C, Wu J, Hess RA, Yan W. Motile cilia of the male reproductive system require miR-34/miR-449 for development and function to generate luminal turbulence. PNAS,  2019 Feb 26; 116(9):3584-3593. DOI: 10.1073/pnas.1817018116.(*Equal contribution)

Wang LL, Li ZH, Duan YG, Yuan SQ, Mor G, Liao AH. Identification of programmed cell death 1 and its ligand in the testicular tissue of mice. Am J Reprod Immunol. 2019 Feb;81(2):e13079.  DOI: 10.1111/aji.13079. 

Yuan Lab




Yuan S, McSinggin H, Zheng H, Yan W. A Testis-Specific Gene, Ubqlnl, Is Dispensable for Mouse Embryonic Development and SpermatogenesisMol Reprod Dev, 2015 Jun;82(6):408-9. DOI: 10.1002/mrd.22504.

Oliver DK, Yuan S, Yan W. Cas9/CRISPR-mediated genome editing results in pervasive genotypic mosaicism in founder mice derived from pronuclear injectionsPLoS ONE ,10(6): e0129457. DOI:10.1371/journal.pone.0129457.

Yuan SQin W, Riordan CR, McSwiggin, H, Zheng H, Yan W. Ubqln3, a testis-specific gene, is dispensable for embryonic development and spermatogenesis in mice. Mol Reprod Dev, 2015 Apr; 82(4):266-7. DOI: 10.1002/mrd.22475.

Yuan S, Oliver DK, Schuster A, Zheng H, Yan W. Breeding scheme and maternal small RNAs affect the efficiency of transgenerational inheritance of a paramutation in mice. Sci Rep, 2015, Mar 18;5:9266.DOI:10.1038/srep09266.

Yuan S, Stratton CJ, Bao J, Zheng H, Bhetwal BP, Yanagimachi, R, Yan W. Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conjunction. PNAS , 2015 Feb 3;112(5):E430-9. DOI: 10.1073/pnas.1424648112.

Yuan S, Tang C, Wu J, Zheng H, Xu C, Yan W. Sperm-borne mir-34b/c and mir-449 are Dispensable for The First Cleavage Division in Mice. Biol Open, 2015, Jan 23;4(2):212-23. DOI: 10.1242/bio.201410959.

Bao J, Tang C, Yuan S, Porse BT, Yan W. UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome. Development, 2015 Jan 15;142(2):352-62. DOI: 10.1242/dev.115642. 

Yuan S, Tang C, Schuster A, Zhang Y, Zheng H, Yan W. Paternal pachytene piRNAs are not required for fertilization, embryonic development and sperm-mediated epigenetic inheritance in mice. Environmental Epigenetics, 2016 Dec;2(4). pii: dvw021. DOI:10.1093/eep/dvw021.

Fededa J, Esk C, Mierzwa B, Stanyte R, Yuan S, Zheng H, Ebnet K, Yan W, Knoblich J & Gerlich D.  microRNA-34/449 controls mitotic spindle orientation during mammalian cortex development. EMBO Journal. 2016 Nov 15;35(22):2386-2398. DOI:10.15252/embj.201694056.

Schuster A, Tang C, Xie Y, Ortogero N, Yuan S, Yan W. SpermBase: a database for sperm RNA contents. Biology of Reproduction, 2016 Nov 1;95(5):99.  DOI: 10.1095/ biolreprod.116.142190.

Yuan S, Schuster AS, Tang C, Ortogero N, Bao J. Zheng H, Yan W. Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation development.  Development, 143(4): 635-647. DOI: 10.1242/dev.131755.

Life is like riding a bicycle. To keep your balance, you must keep moving.

​                                                                                              -Albert Einstein


 Wu J, Bao J*, Kim M*Yuan S*, Tang C*, Zheng H, Mastick GS, Xu C, Yan W. Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis and spermatogenesis. PNAS, 2014 Jul 15; 111(28):E2851-7. DOI: 10.1073/pnas.1407777111. (* Equal contribution)

Yuan S, Ortogero N, Wu Q, Zheng H, Yan W. Murine Follicular Development Requires Oocyte DICER, but Not DROSHA.Biol Reprod, 2014 Aug; 91(2):39. DOI: 10.1095/biolreprod.114.119370. 





​Wen Y, Ma X, Wang X, Wang F, Dong J, Wu Y, Lv C, Liu K, Zhang Y, Zhang Z, Yuan S#hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8/9. Theranostics, 2021 Oct 25;11(20):10030-10046. DOI: 10.7150/thno.66819. eCollection 2021. (#Corresponding author)

Ma Q, Cao C, Zhuang C, Luo X, Li X, Wan H, Ye J, Chen F, Cui L, Zhang Y, Wen Y, Yuan S#, Gui Y#AXDND1, a novel testis-enriched gene, is required for spermiogenesis and male fertility. Cell Death Discov, 2021 Nov 11;7(1):348. DOI: 10.1038/s41420-021-00738-z.  (#Corresponding author)

​Cao C, Duan P, Li W, Guo Y, Zhang J, Gui Y, Yuan S#Lack of miR-379/miR-544 Cluster Resists High-Fat Diet-Induced Obesity and Prevents Hepatic Triglyceride Accumulation in Mice. Front Cell Dev Biol. 2021 Aug 30;9:720900. DOI: 10.3389/fcell.2021.720900. (#Corresponding author)

​Li Z, Zhang Y, Zhang X, Cao C, Luo X, Gui Y, Tang Y, Yuan S#. OTOGL, a gelforming mucin protein, is nonessential for male germ cell development and spermatogenesis in miceReprod Biol Endocrinol. 2021 Jun 26;19(1):95. DOI: 10.1186/s12958-021-00779-0.(#Corresponding author)

Wang L, Yang W, Li B, Yuan S#, Wang F#. Response to stress in biological disorders: Implications of stress granule assembly and function. Cell Prolif. 2021 Jun 25:e13086. DOI: 10.1111/cpr.13086. (#Corresponding author)

Yuan S#, Wang Z, Peng H, Ward SM, Hennig GW, Zheng H, Yan W#Oviductal motile cilia are essential for oocyte pickup but dispensable for sperm and embryo transport. PNAS, 2021 Jun 1;118(22):e2102940118. DOI: 10.1073/pnas.2102940118.(#Corresponding author)

Yu T, Xie Y, Tang C, Wang Y, Yuan S, Zheng H, Yan W. Dnmt2-null sperm block maternal transmission of a paramutant phenotype. Biol Reprod, 2021 Apr 30:ioab086. DOI: 10.1093/biolre/ioab086. 

Gui Y, Yuan S#. Epigenetic regulations in mammalian spermatogenesis: RNA-m6A modification and beyondCell Mol Life Sci, 2021 Apr 9. DOI: 10.1007/s00018-021-03823-9. (#Corresponding author)

Wang X, Wen Y, Zhang J, Swanson G, Guo S, Cao C, Krawetz SA, Zhang Z, Yuan S#MFN2 interacts with Nuage-associated proteins and is essential for male germ cell development by controlling mRNA fate during spermatogenesis. Development, 2021 Mar 5:dev.196295. DOI: 10.1242/dev.196295. (#Corresponding author)

Wu Y, Dong J, Feng S, Zhao Q, Duan P, Xiong M, Wen Y, Lv C, Wang X, Yuan S#Maternal UHRF1 Is Essential for Transcription Landscapes and Repression of Repetitive Elements During the Maternal-to-Zygotic Transition. Front Cell Dev Biol, 2021 Feb 9;8:610773. DOI: 10.3389/fcell.2020.610773.  (#Corresponding author)

Chang Z, Qin W, Zheng H, Schegg K, Han L, Liu X, Wang Y, Wang Z, McSwiggin H, Peng H, Yuan S, Wu J, Wang Y, Zhu S, Jiang Y, Nie H, Tang Y, Zhou Y, Hitchcock MJM, Tang Y, Yan W. Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates. Nat Commun, 2021 Feb 23;12(1):1253. DOI: 10.1038/s41467-021-21517-5.

​​Zhao S, Xie T, Shen L, Liu H, Wang L, Ma X, Wu J, Yuan S, Mor G, Liao A. An Immunological Perspective: What Happened to Pregnant Women After Recovering From COVID-19? Front Immunol, 2021 Feb 3;12:631044. DOI: 10.3389/fimmu.2021.631044.

​Ma X, Guan C, Chen R, Wang Y, Feng S, Wang R, Qu G, Zhao S, Wang F, Wang X, Zhang D, Liu L#, Liao A#Yuan S#Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients. Cell Mol Immunol, 2021 Feb;18(2):487-489. DOI: 10.1038/s41423-020-00604-5. (#Corresponding author)​

Yanagimachi R, Harumi T, Matsubara H, Yan W, Yuan S, Yamaha E, Arai K, Hirohashi K, Tomoriha I, Matsubara T, Andoh T, Vines C, Cherr G.  Chemical and Physical Guidance of Fish Spermatozoa into the Egg through the Micropyle. Biology of Reproduction, 2017 Apr 1;96(4):780-799. DOI:10.1093/biolre/iox015.

Fang N, Cao C, Wen Y, Wang X, Yuan S#, Huang X#MicroRNA profile comparison of testicular tissues derived from successful and unsuccessful microdissection testicular sperm extraction retrieval in non-obstructive azoospermia patients. Reprod Fertil Dev. 2018, Nov 14, 31(4):671-682. DOI: 10.1071/RD17423.(#Corresponding author)

Yin Y, Zhou L#, Yuan S#. Enigma of Retrotransposon Biology in Mammalian Early Embryos and Embryonic Stem Cells.Stem Cells International.  2018 Jul 15; 2018:6239245.DOI:10.1155/2018/6239245.  (#Corresponding author)

Wang X, Wen Y, Dong J, Cao C, Yuan S#Systematic in-depth proteomic analysis of mitochondria-associated endoplasmic reticulum membranes (MAM) in mouse and human testes. Proteomics, 2018 Jul;18(14):e1700478.DOI: 10.1002/pmic.201700478.  (#Corresponding author)

Cao C, Wen Y, Dong J, Wang X, Qin W, Huang X, Yuan S#.  Maternally expressed miR-379/miR-544 cluster is dispensable for testicular development and spermatogenesis in mice. Mol Reprod Dev. 2018 Mar;85(3):175-177.  DOI:10.1002/mrd.22957     (#Corresponding author)

Cao C, Wen Y, Wang X, Fang N, Yuan S#, Huang X#. Testicular piRNA profile comparison between successful and unsuccessful micro-TESE retrieval in NOA patients. J Assist Reprod Genet. 2018 May;35(5):801-808.DOI:10.1007/s10815-018-1134-4   (#Corresponding author)

Wang X, Li J, Yuan S#. Characterization of the protein expression and localization of hnRNP family members during murine spermatogenesisAsian J Androl, 2022 Sep 13. DOI: 10.4103/aja202273. (#Corresponding author)

​Zhou S, Dong J, Xiong M, Gan S, Wen Y, Zhang J, Wang X, Yuan S#, Gui Y#UHRF1 interacts with snRNAs and regulates alternative splicing in mouse spermatogonial stem cells. Stem Cell Reports, 2022 Aug 9; 17: 1-15. DOI: 10.1016/j.stemcr.2022.06.010. (#Corresponding author)

Feng S, Li J, Wen H, Liu K, Gui Y, Wen Y, Wang X, Yuan S#hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cellsNat Commun, 2022 Jun 23;13(1):3588. DOI: 10.1038/s41467-022-31364-7. (#Corresponding author)

Wu Y, Duan P, Wen Y, Zhang J, Wang X, Dong J, Zhao Q, Feng S, Lv C, Guo Y, Namekawa SH, Yuan S#UHRF1 establishes crosstalk between somatic and germ cells in male reproductionCell Death Dis, 2022, Apr 19;13(4):377. DOI: 10.1038/s41419-022-04837-2. (#Corresponding author)

Xiong M, Zhou S, Feng S, Gui Y, Li J, Wu Y, Dong J, Yuan S#UHRF1 is indispensable for meiotic sex chromosome inactivation and interacts with the DNA damage response pathway in mice. Biol Reprod, 2022, Mar 11;ioac054. DOI: 10.1093/biolre/ioac054. (#Corresponding author)

Zhou S, Sakashita A, Yuan S#, Namekawa SH#Retrotransposons in the Mammalian Male GermlineSex Dev, 2022, Mar 1;1-19. DOI: 10.1159/000520683. (#Corresponding author)

Li J, Feng S, Ma X, Yuan S#, Wang X#. METTL21A, a Non-Histone Methyltransferase, Is Dispensable for Spermatogenesis and Male Fertility in Mice. Int. J. Mol. Sci, 2022, 23(4):1942. DOI: 10.3390/ijms23041942. (#Corresponding author)

​Lv C, Xiong M, Guo S, Gui Y, Liu X, Wang X, Wu Y, Feng S, Zhang J, Zhang Y, Liu Y, Qin W#Yuan S#. ​​WDFY1, a WD40 repeat protein, is not essential for spermatogenesis and male fertility in miceBiochem Biophys Res Commun, 2022, Jan 28;596:71-75. DOI: 10.1016/j.bbrc.2022.01.084.  (#Corresponding author)

Wang X, Yin L, Wen Y, Yuan S#. Mitochondrial regulation during male germ cell development. Cell Mol Life Sci, 2022, Jan 24;79(2):91. DOI: 10.1007/s00018-022-04134-3.  (#Corresponding author)

Xu W, Zhang Y, Qin D, Gui Y, Wang S, Du G, Yang F, Li L, Yuan S, Wang M, Wu X. Transcription factor-like 5 is a potential DNA- and RNA-binding protein essential for maintaining male fertility in mice. J Cell Sci. 2022, Feb 1; 135(3):jcs259036. DOI: 10.1242/jcs.259036.